生命情報工学研究センター[CBRC]

研究テーマ

■ [基盤技術開発] 活性化タンパク質相互作用ネットワーク検出技術
■ [基盤技術開発] 表現型相異指向の分子機能同定技術
■ [基盤技術開発] モデリングとシミュレーションの組み合わせによる要因分子絞り込み技術
■ [技術利用] 肺がんプロテオミクスデータ解析によるマーカー探索
■ [技術利用] 細胞リプログラミング機能を利用した抗がん併剤探索
■ [技術利用] ２型糖尿病ラットにおける組織特異的制御要因分子の探索

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Team Member

Katsuhisa Horimoto 堀本　勝久

チーム長 E-mail

website

キーワード

統計的関連・因果推定、代数算法

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論文リスト

• ■ Saito, S., Zhou, X., Bae, T., Kim, S., Horimoto, K.: "Identification of Master Regulator Candidates in Conjunction with Network Screening and Inference.", Int. J. Data Mining and Bioinformatics, in press.
• ■ Piao, G., Saito, S., Sun, Y., Liu, Z., Wang, Y., Han, X., Wu, J., Zhou, H., Chen, L., Horimoto, K.: "A computational procedure for identifying master regulator candidates for diabetes progression in Goto-Kakizaki rat", BMC Sys. Biol., in press.
• ■ Nagamatsu, G., Kosaka, T., Saito, S., Takubo, K., Akiyama, H., Sudo, T., Horimoto, K., Oya, M., Suda, T.: "Tracing the conversion process for primordial germ cells to pluripotent stem cells.", Biology of Reproduction, in press.
• ■ Sun, Y., Saito, S., Horimoto, K., Zhou, H.: "Functional Networks in Diabetes-Progression by Comparison of Gene Expressions from Three Issues of Goto-Kakizaki Rats.", Current Bioinformatics, in press.
• ■ Yu, T., Toshimori, A., Jinrong, X., Saito, S., Zhou, X., Horimoto, K., Fan, Z., Shimizu, K., Zhou, H.: "Cellular relationships of testicular germ cell tumors by partial canonical correlation analysis for gene expression signatures.", Current Bioinformatics, in press.
• ■ Miyagi, Y., Higashiyama, M., Gochi, A., Akaike, M., Ishikawa, T. "Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection." PLoS ONE 6(9): e24143. doi:10.1371/journal.pone.0024143, (2011).
• ■ Zhou, H., Saito, S., Piao, G., Liu, Z., Wang, J., Horimoto, K., Chen, L.: "Network screening of Goto-Kakizaki rat liver microarray data during diabetic progression", BMC Sys. Biol. 5(Suppl 1), S16(2011).
• ■ Saito, S., Onuma, Y., Ito, Y., Tateno, H., Toyoda, M., Akutsu, H., Nishino, K., Chikazawa, E., Fukawatase, Y., Miyagawa, Y., Okita, H., Kiyokawa, N., Shimma, Y., Umezawa, A., Hirabayashi, J., Horimoto, K., Asashima, M.: “Potential linkages between the inner and outer cellular states of human induced pluripotent stem cells.”, BMC Syst Biol. 5 Suppl 1: S17(2011).
• ■ Nakatsui, M., Horimoto, K., Lemaire, F., Ürgüplü, A., Sedoglavic, A., Boulier, F.: "Brute force meets Bruno force in parameter optimisation: introduction of novel constraints for parameter accuracy improvement by symbolic computation", IET Sys. Biol., 5, pp.281-292(2011).
• ■ Tateno, H., Toyota, M., Saito, S., Onuma, Y., Ito, Y., Hiemori, K., Fukumura, M., Matsushima, M., Nakanishi, M., Ohnuma, K., Akutsu, H., Umezawa, A., Horimoto, K., Hirabayashi, J., Asashima, M.: "Glycome Diagnosis of Human Induced Pluripotent Stem Cells Using Lectin Microarray", J. Biol. Chem., 286, pp.20345-20353(2011).
• ■ Saito, S., Hirokawa, T. and Horimoto, K.: "Discovery of Chemical Compound Groups with Common Structures by a Network Analysis Approach.", J. Chem. Inf. Model., 51, pp.61-68(2011).