生命情報工学研究センター[CBRC]

研究テーマ

■配列アラインメント

1.塩基配列の類似配列検索 (LAST)
2.繰り返し配列同定法の改良 (TanTan)

■次世代シーケンサーの誤読修正 (RECOUNT)

■蛋白質細胞内局在予測 (WoLF PSORT)

1.核外以降シグナルの予測 (NESsential)
2.ミトコンドリア蛋白質の局在と切断部位予測
3.マイトソーム・プロテオームの配列解析

■クリックするとオリジナルファイルが開きます。(184KB)

Team Member

Paul Horton ポール・ホートン

チーム長 E-mail

website

キーワード

ゲノム配列解析、蛋白質細胞内局在予測、モチーフ抽出、遺伝子発現解析、次世代シーケンサーのデータ処理技術

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Martin Frith マーティン・フリス

主任研究員

website

E-mail

キーワード

genome evolution, motifs, genome function, alignment, repeats

Kenichiro Imai 今井　賢一郎

研究員

website

E-mail

キーワード

タンパク質細胞内局在予測、局在シグナル解析、アミノ酸配列解析

Thomas Poulsen ﾄｰﾏｽ ﾎﾟｰﾙｾﾝ

産総研
特別研究員

website

E-mail

キーワード

Sequence alignment, Series quantification, Localization prediction.

論文リスト

• ■ "Mammalian NUMT insertion is non-random",
  Junko Tsuji, Martin C. Frith, Kentaro Tomii & Paul Horton
  Nucleic Acids Research, in press.
• ■ "A mostly traditional approach improves alignment of bisulfite-converted DNA",
  Martin C. Frith, Ryota Mori & Kiyoshi Asai
  Nucleic Acids Research, 2012.
• ■ "RecountDB: a database of mapped and count corrected transcribed sequences",
  Edward Wijaya, Martin C. Frith, Kiyoshi Asai & Paul Horton
  Nucleic Acids Research, (2012 NAR Database Issue)
• ■ "Prediction of leucine-rich nuclear export signal containing proteins with NESsential",
  Szu-Chin Fu, Kenichiro Imai & Paul Horton
  published online Nucleic Acids Research, June 24, 2011.
• ■ "Eukaryotic-wide sequence analysis of mitochondrial β-barrel outer membrane proteins",
  Kenichiro Imai, Naoya Fujita, M. Micheal Gromiha & Paul Horton
  BMC Genomics, 12:79, 2011.
• ■ "Adaptive seeds tame genomic sequence comparison",
  S.M. Kie?basa, Raymond Wan, Kengo Sato, Paul Horton & Martin C. Frith
  Genome Research, 21:487-93, 2011.
• ■ "A new repeat-masking method enables specific detection of homologous sequences",
  Martin C. Frith
  Nucleic Acids Research, 39:e23, 2010.
• ■ "Incorporating sequence quality data into alignment improves DNA read mapping",
  Martin C. Frith, Raymond Wan & Paul Horton
  Nucleic Acids Research, 38(7):e100, 2010.
• ■ "Parameters for accurate genome alignment",
  Martin C. Frith, Michiaki Hamada & Paul Horton
  BMC Bioinformatics 11:80, Feb 9 2010.
• ■ "Mitochondrial β-Barrel Proteins, an Exclusive Club?"(Correspondence),
  Kenichiro Imai, M. Michael Gromiha & Paul Horton
  Cell, 135(7):1158-9, 2008.