Publication List

Original Papers

Bioinformatics

Biophysics of DNA Molecules

Cytochrome P450 and Related Systems

Transcription Factors and Gene Regulation

Mitochondrial DNA and Genetics

Others

Reviews and Book Chapters

Bioinformatics and Biophysics

P450 and Related Systems

Others

Japanese Publications

[Original Papers]

Bioinformatics

• Gotoh, O. (2000) Homology-based gene structure prediction: simplified matching algorithm using a translated colon (ton) and improved accuracy by allowing for long gaps. Bioinformatics, 16, (3) 190-202.
  
• Gotoh, O. (1998) Divergent structures of Caenorhabditis elegans cytochrome P450 genes suggest the frequent loss and gain of introns during the evolution of nematodes. Mol. Biol. Evol. 15, 1447-1459.
  
• Gotoh, O. (1996) Significant improvement in accuracy of multiple protein sequence alignments by iterative refinement as assessed by reference to structural alignments. J. Mol. Biol. 264, 823-838.
  
• Gotoh, O. (1995) A weighting system and algorithm for aligning many phylogenetically related sequences. Comput. Applic. Biosci., 11, 543-551.
  
• Gotoh, O. (1994) Further improvement in methods of group-to-group sequence alignment with generalized profile operations. Comput. Applic. Biosci. 10, 379-387.
  
• Gotoh, O. (1993) Optimal alignment between groups of sequences and its application to multiple sequence alignment. Comput. Applic. Biosci. 9, 361-370.
• Gotoh, O. (1990) Consistency of optimal sequence alignments. Bull. Math. Biol. 52, 509-525.
  
• Gotoh, O. (1990) Optimal sequence alignment allowing for long gaps. Bull. Math. Biol. 52, 359-373.
  
• Gotoh, O. (1987) Pattern matching of biological sequences with limited storage. Comput. Applic. Biosci. 3, 17-20.
  
• Gotoh, O. (1986) Alignment of three biological sequences with an efficient traceback procedure. J. Theor. Biol. 121, 327-337.
  
• Gotoh, O. and Tagashira, Y. (1986) Sequence search on a supercomputer. Nucl. Acids Res. 14, 57-64.
  
• Takeishi, K. and Gotoh, O. (1982) Computer analysis of the sequence relationships among 4.5S RNA molecular species from various sources. J. Biochem. (Tokyo) 92, 1173-1177.
  
• Gotoh, O. (1982) An improved algorithm for matching biological sequences. J. Mol. Biol. 162, 705-708.
  
• Gotoh, O., Hayashi, J.-I., Yonekawa, H. and Tagashira, Y. (1979) An improved method for estimating sequence divergence between related DNAs from changes in restriction endonuclease cleavage sites. J. Mol. Evol. 14, 301-310.
  

Biophysics of DNA Molecules

• Tachibana, H., Ueno-Nishio, S., Gotoh, O. and Wada, A. (1982) Salt-concentration dependence of thermal denaturation of restriction fragment DNAs from fX174. J. Biochem. (Tokyo) 92, 623-635.
  
• Gotoh, O. and Tagashira, Y. (1981) Locations of frequently opening regions on natural DNAs and their relation to functional loci. Biopolymers 20, 1043-1058.
  
• Gotoh, O. and Tagashira, Y. (1981) Stabilities of nearest-neighbor doublets in double-helical DNA determined by fitting calculated melting profiles to observed profiles. Biopolymers 20, 1033-1042.
  
• Gotoh, O., Wada, A. and Yabuki, S. (1979) Salt-concentration dependence of melting profiles of lambda phage DNAs: Evidence for long-range interactions and pronounced end effects. Biopolymers 18, 805-824.
  
• Yonekawa, H., Gotoh, O., Motohashi, J., Hayashi, J.-I. and Tagashira, Y. (1978) Positioning of the AT-rich regions in rat mitochondrial DNA by electron microscopy and analysis of the hysteresis of denaturation. Biochim. Biophys. Acta 521, 510-519.
  
• Tachibana, H., Wada, A., Gotoh, O. and Takanami, M. (1978) Location of the cooperative melting regions in bacteriophage fd DNA. Biochim. Biophys. Acta 517, 319-328.
  
• Gotoh. O., Wada, A., Tada, M. and Tada, M. (1978) Base and base sequence specificity of the binding of 4-hydroxyaminoquinoline 1-oxide to DNA. Gann 69, 61-66.
• Akiyama, C., Gotoh, O. and Wada, A. (1977) Spectral analysis on the melting fine structure of lDNA and T2 DNA. Biopolymers 16, 427-435.
  
• Wada, A., Tachibana, H., Gotoh, O. and Takanami, M. (1976) Long-range homogeneity of physical stability in double-stranded DNA. Nature 263, 439-440.
  
• Gotoh, O., Husimi, Y., Yabuki, S. and Wada, A. (1976) Hyperfine structure in melting profiles of bacteriophage lambda DNA. Biopolymers 15, 655-670.
  
• Yabuki, S., Gotoh, O. and Wada, A. (1975) Fine structures in denaturation curves of bacteriophage lambda DNA. I. Their relation to the intra-molecular heterogeneity in base composition. Biochim. Biophys. Acta 395, 258-273.
  

Cytochrome P450 and Related Systems

• Nitahara, Y., Kishimoto, K., Yabusaki, Y., Gotoh, O., Yoshida, Y., Horiuchi, T., Aoyama, Y. (2001) The amino acid residues affecting the activity and azole susceptibility of rat CYP51 (sterol 14-demethylase P450). J. Biochem. 129, 761-768.
  
• Yoshida, Y., Aoyama, Y., Noshiro, M., and Gotoh, O. (2000) Sterol 14-Demethylase P450 (CYP51) provides a breakthrough for the discussion on the evolution of cytochrome P450 gene superfamily, Biochem. Biophys. Res. Commun. 273, 799-804.
  
• Aoyama, Y., Kudo, M., Asai, K., Okonogi, K., Horiuchi, T., Gotoh, O., and Yoshida, Y. (2000) Emergence of fluconazole-resistant sterol 14-demethylase P450 (CYP51) in Candida albicans is a model demonstrating the diversification mechanism of P450. Arch. Biochem. Biophys., 379, 170-171.
  
• Watanabe, J., Shimada, T., Gillam, E.M.J., Ikuta, T., Suematsu, K., Higashi, Y., Gotoh, O., and Kawajiri, K. (2000) Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics, 10, 25-33.
  
• Asai, K., Tsuchimori, N., Okonogi, K., Perfect, J.R., Gotoh, O., and Yoshida, Y. (1999) Formation of azole-resistant Candida albicans by mutation of sterol 14-demethylase P450. Antimicrob. Agents Chemother. 43, (5) 1163-1169.
  
• Ishida, H., Kuruta, Y., Gotoh, O., Yamashita, C., Yoshida, Y., and Noshiro, M. (1999) Structure, evolution, and liver-specific expression of sterol 12a-hydroxylase P450 (CYP8B). J. Biochem.. 126, (1) 19-25.
  
• Aoyama, Y., Horiuchi, T., Gotoh, O., Noshiro, M., and Yoshida, Y. (1998) CYP51-Like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51. J. Biochem., 124, 695-696.
  
• Yoshida, Y., Noshiro, M., Aoyama, Y., Kawamoto, T., Horiuchi, T., and Gotoh, O. (1997) Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase II. Evolutionary analysis of protein and gene structures. J. Biochem., 122, 1122-1128.
  
• Noshiro, M., Aoyama, Y., Kawamoto, T., Gotoh, O., Horiuchi, T., and Yoshida, Y. (1997) Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase I. Structural analyses of the gene and multiple sizes of mRNA. J. Biochem. 122, 1114-1121.
  
• Watanabe, J., Harada, N., Suemasu, K., Higashi, Y., Gotoh, O., and Kawajiri, K. (1997) Arginine-cysteine polymorphism at colon 264 of the human CYP19 gene does not affect aromatase activity. Pharmacogenetics, 7, 419-424.
  
• Matsunaga, I., Yokotani, N., Gotoh, O., Kusunose, E., Yamada, M., and Ichihara, K. (1997) Molecular cloning and expression of fatty acid - hydroxylase from Sphingomonas paucimobilis. J. Biol. Chem. 272, 23592-23596.
  
• Fujii, T., Nakamura, K., Shibuya, K., Tanase, S., Gotoh, O., Ogawa, T., and Fukuda, H. (1997) Structural characterization of the gene and corresponding cDNA for the cytochrome P450rm from Rhodotorula minuta which catalyzes formation of isobutene and 4-hydroxylation of benzoate. Mol. Gen. Genet. 256, 115-120.
  
• Fujii, H., Sato, T., Kaneko, S., Gotoh, O., Fujii-Kuriyama, Y., Osawa, K., Kato, S., and Hamada, H. (1997) Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 16, 4163-4173.
  
• Nelson, D.R., Koymans, L., Kamataki, T., Stegeman, J.J., Feyereisen, R., Waxman, D.J., Waterman, M.R., Gotoh, O., Coon, M.J., Estabrook, R.W., Gunsalus, I.C., and Nebert, D.W. (1996) P450 superfamlily: Update on new sequences, gene mapping, accession numbers, and nomenclature. Pharmacogenetics, 6, 1-42.
  
• Aoyama, Y., Noshiro, H., Gotoh, O., Imaoka, S., Funae, Y., Kurosawa, N., Horiuchi, T., and Yoshida, Y. (1996) Sterol 14-demethylase P450 (P45014DM) is one of the most ancient and conserved P450 species. J. Biochem., 119, 926-933.
  
• Nelson, D.R., Kamataki, T., Waxman, D.J., Guengerich, F.P., Estabrook, R.W., Feyereisen, R., Gonzalez, F.J., Coon, M.J., Gunsalus, I.C., Gotoh, O., Okuda, K., and Nebert, D.W. (1993) The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51.
  
• Ohyama, Y., Noshiro, H., Gotoh, O., Kato, Y., Bjorkhem, I., and Okuda, K. (1993) Structural characterization of the gene encoding rat 25-hydroxyvitamin D3 24-hydroxylase. Biochemistry 32, 76-82.
  
• Gotoh, O. (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267, 83-90.
  
• Kubota, M., Sogawa, K., Kaizu, Y., Sawaya, T., Watanabe, J., Kawajiri, K., Gotoh, O., and Fujii-Kuriyama, Y. (1991) Xenobiotic responsive element in the 5’-upstream region of the human P-450c gene. J. Biochem. 110, 232-236.
  
• Kizawa, H., Tomura, D., Oda, M., Fukamizu, A., Hoshino, T., Gotoh, O., Yasui, T., and Shoun, H. (1991) Nucleotide sequence of the unique nitrate/nitrite-inducible cytochrome P-450 cDNA from Fusarium oxysporum. J. Biol. Chem. 266, 10632-10637.
  
• Nishimoto, M., Gotoh, O., Okuda, K., and Noshiro, M. (1991) Structural analysis of the gene encoding rat cholesterol 7a-hydroxylase, the key enzyme for bile acid biosynthesis. J. Biol. Chem. 266, 6467-6471.
  
• Yokotani, N., Sogawa, K., Matsubara, S., Gotoh, O., Kusunose, E., Kusunose, M. and Fujii-Kuriyama, Y. (1990) cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression. Eur. J. Biochem. 187, 23-29.
  
• Yokotani, N., Bernhardt, R., Sogawa, K., Kusunose, E., Gotoh, O., Kusunose, M., and Fujii-Kuriyama, Y. (1989) Two forms of omega-hydroxylase toward prostaglandin A and laurate. cDNA cloning and their expression. J. Biol. Chem. 264, 21665-21669.
  
• Matsubara, S., Yamamoto, S., Sogawa, K., Yokotani, N., Fujii-Kuriyama, Y., Haniu, M., Shively, J.E., Gotoh, O., Kusunose, E. and Kusunose, M. (1987) cDNA cloning and inducible expression during pregnancy of the mRNA for rabbit pulmonary prostaglandin-hydroxylase (cytochrome P-450p-2). J. Biol. Chem. 262, 13366-133701.
  
• Morohashi, K., Yoshioka, H., Gotoh, O., Okada, Y., Yamamoto, K., Miyata, T., Sogawa, K., Fujii-Kuriyama, Y., and Omura, T. (1987) Molecular cloning and nucleotide sequence of DNA of mitochondrial cytochrome P-450(11b) of bovine adrenal cortex. J. Biochem. (Tokyo) 101, 879-887.
  
• Kawajiri, K., Watanabe, J., Gotoh, O., Tagashira, Y., Sogawa, K. and Fujii-Kuriyama, Y. (1986) Structure and drug inducibility of human cytochrome P450c gene. Eur. J. Biochem. 159, 219-225.
  
• Higashi, Y., Yoshioka, H., Yamane, M., Gotoh, O. and Fujii-Kuriyama, Y. (1986) Complete nucleotide sequence of two steroid 21-hydroxyﾐlase genes tandemly arranged in human chromosome: A pseudogene and a genuine gene. Proc. Natl. Acad. Sci. USA 83, 2841-2845.
  
• Gotoh, O., Tagashira, Y., Morohashi, K. and Fujii-Kuriyama, Y. (1985) Possible steroid binding site common to adrenal cytochrome P-450scc and prostatic steroid binding protein. FEBS Lett. 188, 8-10.
  
• Sogawa, K., Gotoh, O., Kawajiri, K., Harada, T. and Fujii-Kuriyama, Y. (1985) Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. J. Biol. Chem. 260, 5026-5032.
  
• Kawajiri, K., Gotoh, O., Tagashira, Y., Sogawa, K. and Fujii-Kuriyama, Y. (1984) Titration of mRNA for cytochrome P-450c and P-450d under drug-inductive conditions in rat livers by their specific probes of cloned DNAs. J. Biol. Chem. 259, 10145-10149.
  
• Sogawa, K., Gotoh, O., Kawajiri, K. and Fujii-Kuriyama, Y. (1984) Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat. Proc. Natl. Acad. Sci. USA 81, 5066-5070.
  
• Kawajiri, K., Gotoh, O., Sogawa, K., Tagashira, Y., Muramatsu, M. and Fujii-Kuriyama, Y. (1984) Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver. Proc. Natl. Acad. Sci. USA 81, 1649-1653.
  
• Kawajiri, K., Sogawa, K., Gotoh, O., Tagashira, Y., Muramatsu, M. and Fujii-Kuriyama, Y. (1983) Molecular cloning of a complementary DNA to 3-methylcholanthrene-inducible cytochrome P-450 mRNA from rat liver. J. Biochem. (Tokyo) 94, 1465-1473.
  
• Kawajiri, K., Yonekawa, H., Gotoh, O., Watanabe, J., Igarashi, S. and Tagashira, Y. (1983) Contributions of two inducible forms of cytochrome P-450 in rat liver microsomes to the metabolic activation of various chemical carcinogens. Cancer Res. 43, 819-823.
  
• Gotoh, O., Tagashira, Y. Iizuka, T. and Fujii-Kuriyama, Y. (1983) Structural characteristics of cytochrome P-450. Possible location of the heme-binding cysteine in determined amino-acid sequences. J. Biochem. (Tokyo) 93, 807-817.
  
• Hara, E., Kawajiri, K., Gotoh, O. and Tagashira, Y. (1981) Immunochemical study on the contributions of two molecular species of microsomal cytochrome P-450 to the metabolism of 2-acetylaminofluorene by rat liver microsomes. Cancer Res. 41, 253-257.
  

Transcription Factors and Gene Regulation

• Teramoto, M., Nakamatsu, K., Noshiro, M., Matsuda, Y., Gotoh, O., Shen, M., Tsutsumi, S., Kawamoto, T., Iwamoto, Y., Kato, Y. (2001) Gene structure and chromosomal location of a human bHLH transcriptional factor J. Biochem. 129, 391-396
  
• Kimura, R., Yoshii, H., Nomura, M., Kotomura, N., Mukai, T., Ishihara, S., Ohba, K., Yanase, T., Gotoh, O., Nawata, H., Morohashi, K. (2000) Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage. Biochem Biophys Res Commun. 278, 63-71.
  
• Kojima, S., Kobayashi, A., Gotoh, O., Ohkuma, Y., Fujii-Kuriyama, Y., and Sogawa, K. (1997) Transcriptional activation domain of human BTEB2, a GC box-binding factor. J. Biochem. 121, 389-396.
  
• Ema, M., Morita, M., Ikawa, S., Tanaka, M., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., Kikuchi, Y., and Fujii-Kuriyama, Y. (1996) Two new members of murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol. Cell. Biol. 16, 5865-5875.
  
• Hirose, K., Morita, M., Ema, M., Mimura, J., Hamada, H., Fujii, H., Saijo, Y., Gotoh, O., Sogawa, K., and Fujii-Kuriyama, Y. (1996) cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16, 1706-1713.
  
• Ema, M., Suzuki, M., Morita, M., Hirose, K., Sogawa, K., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., and Fujii-Kuriyama, Y. (1996) cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization. Biochem. Biophys. Res. Commun. 218, 588-594.
  
• Eguchi, H., Hayashi, S.-i., Watanabe, J., Gotoh, O., and Kawajiri, K. (1994) Molecular cloning of the human Ah receptor gene promoter. Biochem. Biophys. Res. Commun. 203, 615-622.
  
• Hayashi, S.-i., Watanabe, J., Nakachi, K., Eguchi, H., Gotoh, O., and Kawajiri, K. (1994) Interindividual difference in expression of human Ah receptor and related P450 genes. Carcinogenesis 15, 801-806.
  
• Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y., and Fujii-Kuriyama, Y. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophys. Res. Commun. 184, 246-253.
  

Mitochondrial DNA and Genetics

• Yonekawa, H., Moriwaki, K., Gotoh, O., Miyashita, N., Matsushima, Y., Shi, L., Cho, W.S., Zhen, X.-L. and Tagashira, Y. (1988) Hybrid origin of Japanese Mice “Mus musculus molossinus”: Evidence from restriction analysis of mitochondrial DNA. Mol. Biol. Evol. 5, 63-78.
  
• Yonekawa, H., Gotoh, O., Tagashira, Y., Matsushima, Y., Shi, L., Cho, W.S., Miyashita, N. and Moriwaki, K. (1986) Hybrid origin of Japanese mice “Mus musculus molossinus”. Curr. Top. Microbiol. Immunol. 127, 76-81.
  
• Moriwaki, K., Yonekawa, H., Gotoh, O., Minezawa, M., Winking, H. and Gropp, A. (1984) Implications of the genetic divergence between European wild mice with Robertsonian translocations from the viewpoint of mitochondrial DNA. Genet. Res. Camb. 43, 277-287.
  
• Yonekawa, H., Moriwaki, K., Gotoh, O., Miyashita, N., Migita, S., Bonhomme, F., Hjorth, J.P., Petras, M.L. and Tagashira, Y. (1982) Origin of laboratory mice deduced from restriction patters of mitochondrial DNA. Differentiation 22, 222-226.
  
• Hayashi, J.-I., Gotoh, O., Tagashira, Y., Tosu, M., Sekiguchi, T. and Yoshida, M.C. (1982) Mitochondrial DNA analysis of mouse-rat hybrid cells: Effect of chloramphenicol selection on the relative amounts of parental mitochondrial DNAs. Somat. Cell Genet. 8, 67-81.
  
• Yonekawa, H., Moriwaki, K., Gotoh, O., Hayashi, J.-I., Watanabe, J., Miyashita, N., Petras, M.L. and Tagashira, Y. (1981) Evolutionary relationships among five subspecies of Mus musculus based on restriction enzyme cleavage patterns of mitochondrial DNA. Genetics 98, 801-816.
  
• Hayashi, J.-I., Gotoh, O., Tagashira, Y., Tosu, M. and Sekiguchi, T. (1981) Analysis of mitochondrial DNA species in interspecific hybrid somatic cells using restriction endonucleases. Exp. Cell Res. 131, 458-462.
  
• Hayashi, J.-I., Gotoh, O. and Tagashira, Y. (1981) Length polymorphisms of restriction fragments of rat mitochondrial DNAs. Biochem. Biophys. Res. Commun. 98, 936-941.
  
• Hayashi, J.-I., Gotoh, O. and Tagashira, Y. (1980) A general characteristic of tumor mitochondria: Leakage of endogenous Mg2 on incubation with uncoupler and resultant reduction of uncoupler-stimulated ATPase activity. Arch. Biochem. Biophys. 205, 27-35.
  
• Hayashi, J.-I., Gotoh, O., Tagashira, Y. Tosu, M. and Sekiguchi, T. (1980) Identification of mitochondrial DNA species in interspecific cybrids and reconstituted cells using restriction endonucleases. FEBS Lett. 117, 59-62.
  
• Yonekawa, H., Moriwaki, K., Gotoh, O., Watanabe, J., Hayashi, J.-I., Miyashita, N., Petras, M.L. and Tagashira, Y. (1980) Relationship between laboratory mice and the subspecies Mus musculus domesticus based on restriction endonuclease cleavage patterns of mitochondrial DNA. Jpn. J. Genetics 55, 289-296.
  
• Hayashi, J.-I., Yonekawa, H., Gotoh, O. and Tagashira, Y. (1980) Unique uncoupler-stimulation pattern of mitochondrial ATPase activity of tumor cells, brain, and fetal liver. Biochem. Biophys. Res. Commun. 92, 261-267.
  
• Hayashi, J.-I., Yonekawa, H., Gotoh, O., Tagashira, Y., Moriwaki, K. and Yoshida, T.H. (1979) Evolutionary aspects of variant types of rat mitochondrial DNAs. Biochim. Biophys. Acta 564, 202-211.
  
• Hayashi, J.-I., Yonekawa, H., Gotoh, O., Watanabe, J. and Tagashira, Y. (1978) Strictly maternal inheritance of rat mitochondrial DNA. Biochem. Biophys. Res. Commun. 83, 1032-1038.
  
• Hayashi, J.-I., Yonekawa, H., Gotoh, O., Motohashi, J. and Tagashira, Y. (1978) The differences of the primary structures between mitochondrial DNAs from rat liver and AH-130 hepatoma. Cancer Letters 4, 125-130.
  
• Hayashi, J.-I., Yonekawa, H., Gotoh, O., Motohashi, J. and Tagashira, Y. (1978) Two different molecular types of rat mitochondrial DNAs. Biochem. Biophys. Res. Commun. 81, 871-877.
  

Others

• Nakamatsu, K., Kawamoto, T., Ming, S., Gotoh, O., Teramoto, M., Noshiro, H., and Kato, Y. (1999) Membrane-bound transferrin-like protein (MTf): structure, evolution, and selective expression during chondrogenic differentiation of mouse embryonic cells. Biochim. Biophys. Acta. 1447, (2-3) 258-264.
  
• Kawamoto, T., Noshiro, M., Shen, M., Nakamasu, K., Hashimoto, K., Kawashima-Ohya, Y., Gotoh, O., and Kato, Y. (1998) Structural and phylogenetic analyses of RGD-CAP/big-h3, a fasciclin-like adhesion protein expressed in chick chondrocytes. Biochim. Biophys. Acta, 1395, 288-292.
  
• Tomida, M., and Gotoh, O. (1996) Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor. J. Biochem., 120, 201-205.
  
• Niwa-Kawakita, M., Miyoshi, H., Gotoh, O., Matsushima, Y., Nishimura, M., Sisa, H., and Ohki, M. (1995) Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia. Genomics, 29, 755-759.
  
• Koike, S., Ise, I., Sato, Y., Yonekawa, H., Gotoh, O., and Nomoto, A. (1992) A Second Gene for the African green monkey poliovirus receptor that has no putative N-glycosylation site in the functional N-terminal immunoglobulin-like domain. J. Virol. 66, 7059-7066.
  
• Ishihara, S., Morohashi, K.-i., Sadano, H., Kawabata, S.-i., Gotoh, O., and Omura, T. (1990) Molecular cloning and sequence analysis of cDNA coding for rat liver hemoprotein H-450. J. Biochem. 108, 899-902.
  
• Kaneda, S., Nalbantoglu, J., Takeishi, K., Shimizu, K., Gotoh, O., Seno, T. and Ayusawa, D. (1990) Structural and functional analysis of the human thymidylate synthase gene. J. Biol. Chem. 265, 20277-20284.
  
• Suzuki, H., Tsuchiya, K., Sakaizumi, M., Wakana, S., Gotoh, O., Saitou, N., Moriwaki, K. and Sakurai, S. (1990) Differentiation of restriction sites in ribosomal DNA in the genus Apodemus. Biochem. Genet. 28, 137-149.
  
• Takeishi, K., Kaneda, S., Ayusawa, D., Shimizu, K., Gotoh, O. and Seno, T. (1989) Human thymidylate synthase gene: Isolation of phage clones which cover a functionally active gene and structural analysis of the region upstream from the translation initiation colon. J. Biochem. (Tokyo) 106, 575-583.
  
• Takeishi, K., Kaneda, S., Ayusawa, D., Shimizu, K., Gotoh, O. and Seno, T. (1985) Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucl. Acids Res. 13, 2035-2043.
  
• Kaneda, S., Gotoh, O., Seno, T. and Takeishi, K. (1983) Nucleotide sequence of Dictyostelium small nuclear RNA Dd8 not homologous to any other sequenced small nuclear RNA. J. Biol. Chem. 258, 10606-10613.
  
• Kinoshita, K., Jr., Kataoka, R., Kimura, Y., Gotoh, O. and Ikegami, A. (1981) Dynamic structure of biological membranes as probed by 1,6-diphenyl-1,3,5-hexatriene: A nanosecond fluorescence depolarization study. Biochemistry 20, 4270-4277.
  
• Hayashi, M., Gotoh, O., Okabe-Kado, J. and Hozumi, M. (1981) Mechanisms controlling the kinetics in proliferation and differentiaﾐtion of populations of mouse myeloid leukemic cells in vitro. J. Cell. Physiol. 108, 123-134.
  

[Reviews and Book Chapters]

Bioinformatics and Biophysics

• Gotoh, O. (1999) Multiple sequence alignment: algorithms and applications. Adv. Biophys. 36, 159-206.
  
• Gotoh, O. (1994) Multiple sequence Alignment with a tree-based weighting system. in The Proceedings of Genome Informatics Workshop V, pp. 182-183.
  
• Gotoh, O. (1993) Extraction of conserved and variable regions from a multiple sequence alignment. in The Proceedings of Genome Informatics Workshop IV, pp. 109-113.
  
• Gotoh, O. (1983) Prediction of melting profiles and local helix stability for sequenced DNA. Adv. Biophys. 16, 1-52.
  
• Tachibana, H., Gotoh. O. and Wada, A. (1981) High resolution thermal melting studies of DNA. in Progress in Clinical and Biological Research: Bacteriophage Assembly, Vol. 64, pp. 299-313, Alan R. Liss Inc. New York.
  

P450 and Related Systems

• Yoshida, Y., Aoyama, Y., Noshiro, M., and Gotoh, O. (1999) Sterol 14-demethylase (CYP51), the most widely distributing P450: functional conservation and modulation. in 2nd BRAIN Seminar, Cytochrome P450 and plant genetic engineering, pp. 5-9.
  
• Yoshida, Y., Aoyama, Y., Noshiro, H., and Gotoh, O. (1999) Evolution and functional diversification of sterol-metabolizing P450: evidence for the interaction between diversification of P450 and expansion of metabolic pathways. Curr. Topics Biochem. Res. 1, 103-112.
  
• Fujii-Kuriyama, Y. and Gotoh, O. (1995) Molecular biology of cytochrome P-450; evolution, structure and regulation. in Molecular Aspects of Oxidative Drug Metabolizing Enzymes (Arinc, E., Schenkman, J.B., and Hodgson, E., eds.) NATO ASI Series, Vol. H.90, pp.65-85, Springer, Berlin.
  
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• Yonekawa, H., Takahama, S., Gotoh, O., Miyashita, N., and Moriwaki, K. (1994) Genetic diversity and geographic distribution of Mus musculus subspecies based on the polymorphism of mitochondrial DNA. in Genetics in Wild Mice: Its Application to Biomedical Research (Moriwaki, K., Shiroishi, T., and Yonekawa, H., eds.) pp. 25-40, Japan Scientific Societies, Tokyo.